It's only a matter of time, when it comes to handheld platforms, that someone makes a game that forces you to use it in a way that hasn't been done before. Frankly, this isn't always successful, but it can have some interesting results. For instance, it was definitely annoying but surprisingly innovative when Kojima forced you to go out in the sun for Boktai. And we all know what game uses the DS in a vertical stance. In fact, most of this kind of thing has been relegated to the DS, until now.
Anata wo Yurusanai (which roughly means "I won't forgive you") has a female detective as a main character, and shockingly, the music is by none other than Nobuo Uematsu! Created by AQ Interactive and due out in Japan in November, you can use the analog stick to hide behind walls as you tail your suspects.
haven't got around to playing this one yet but when i do, i'll post what i think..