Just some predictions I have. You don't have to be einstein to come up with these as they aren't particularly original, just interested to hear what others think is around the corner...
Revised UMD Copy Protection
I think Sony, after a particularly weak effort (or I should be more kind and say strong effort by the s) with the existing UMD format, will come out with much stronger protected UMD formats. The reason how they can do this, is of course due to the fact that they are the only ones pressing them. The way I guess it would work is that you would have a small partition on the disc that includes the necessary firmware update, followed by a partition containing the new UMD format. If they get that right, then the dumping suddenly ceases and upgrades can be more strongly enforced/controlled. Now the question is, would Sony be so heavy handed as to do such a thing? Personally I think it could be a bit over the top, but seriously, if you look at audio CDs you can see a strong trend in copy protection, which in a lot of cases limits the use for the consumer of the medium. Quite scary, but it's there and the manufacturers aren't afraid to do it. Also, Sony is already forcing us to do this to a degree with the new UMD's that force an upgrade (perhaps this is already what I am speculating: a new format UMD? It would be great if someone who really knew the details could clarify).
Revised Firmware Version checking
I think the next round of games are going to use a different version of firmware version detection (and they don't all have to use the same method). Of course, nothing surprising here, but the way they go about it can potentially make it hard to avoid without manually patching the dumps rather than modifying firmware signatures.
Online Multiplayer Validation
Again, this one isn't particularly surprising, but it will be very interesting to see how SOCOM does this, as it would set the scene for the future. I guess the way things work with HalfLife etc is already reasonably strong where a you need a valid serial number to use it (of course, I know, keygens)... but in this situation they can most likely use your PSP's MAC address, which unlike the PC cards (due to an ability to alter), can be guaranteed to be unique.
So, out of these 3 I see the first one as possibly the least possible to anticipate because the second two look more than likely. Either way, it's going to be interesting to sit on the sidelines and watch the battle between the s and Sony. I think we are really in the twighlight of PSP evolution and it will be quite interesting to see how things pan out. I have no problems with Sony protecting their system as I like it enough to supported it with legitimately purchased titles, but I think they must realise that there is a strong need for an official development system to come out from Sony to allow people to create their own applications to run on the PSP as it is a waste of potential for many to not be able to do that.